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Drug Alerts


Drug Alerts

The preliminary analysis of SUSARs from the PvPI database reveals that the following drugs are associated with the risks as given below.

Table

S.No

Suspected Drugs

Indication

Adverse Reactions

1

Phenytoin

Generalized tonic-clonic seizures; partial

seizures; status epilepticus

 

Angioedema

2

Phenytoin

Generalized tonic-clonic seizures; partial

seizures; status epilepticus

 

Osteoporosis

3

Nicorandil

Angina Pectoris, Vasodialator

Risk of ulcer complication

4

Olanzapine

Schizophrenia, acute mania episodes in

bipolar disorder

 

Hyponatraemia

5

Crizotinib

Locally advanced or metastatic non-small cell lung cancer (NSCLC) that is anaplastic lymphoma kinase (ALK)

Risk of cardiac failure

6

Sunitinib & Pazopanib

 

Cardiac Dysfunction

7

Ambroxol

 

Anaphylactic Reactions, SJS/ TEN, Scars including Erythema Multiforme

8

Rabies Vaccine

 

Erythema Multiforme/ Stevens–Johnson syndrome

9

Sodium Valproate

 

Slurred Speech

10

Meropenem

 

Ludwig Angina (Cellulitis)

11.

Ticagrelor

 

Monoparesis

12.

Roflumilast

Reduce the risk of Chronic Obstructive Pulmonary Diseases exacerbations.

Gynecomastia

13.

Clozapine

Management of Schizophrenic patients.

Neutropenia

14.

Disulfiram

Alcohol-Abuse Deterrent

Erythroderma

Health care professionals, Patients/Consumers are advised to closely monitor the possibility of the above adverse events while prescribing/consuming above suspected drugs and report to the NCC-PvPI either by filling of Suspected Adverse Drug Reactions Reporting Form/
Medicines Side Effect Reporting Form for Consumer (http://www.ipc.gov.in) or by PvPI Helpline no. 18001803024.